Is this your crossword clue?
"unease" is also used as a crossword clue. If that's what you saw, the answer is often discomfort (10 letters).
Definitions
the trait of seeming ill at ease
Word origin
From Middle English unese, equivalent to un- + ease. Compare disease.
Used in a sentence
“And she'll tease you / She'll unease you / All the better just to please you”
Source: Wiktionary, CC BY-SA 4.0
Used as a crossword answer1 curated clues
01“Anxious feeling”6 letters
Not quite right?
"Search similar patterns."
U_____