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"unfavorable" is also used as a crossword clue. If that's what you saw, the answer is often adverse (7 letters).
Definitions
involving or creating circumstances detrimental to success or effectiveness
Word origin
From un- + favorable.
Used in a sentence
“Microrefugia are sites that support populations of species when their ranges contract during unfavorable climate episodes.”
“Alternatively, unfavorable outcome with severe or even fatal consequences for the organism would be the development of fibrolipid plaque which would be prone to plaque rupture and thrombus formation [ 23 ].”
Source: Wiktionary, CC BY-SA 4.0
Used as a crossword answer1 curated clues
01“Adverse”11 letters
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